2-Hydroxy-3,3-dimethyl-7-nitro-3,4-dihydroisoquinolin-1(2H)-one
نویسندگان
چکیده
In the title compound, C(11)H(12)N(2)O(4), a new hydroxamic acid which belonging to the isoquinole family, the heterocyclic ring adopts a half-chair conformation. The nitro group is essentially coplanar with the aromatic ring. Inter-molecular O-H⋯O hydrogen bonds assemble the mol-ecules around inversion centres to form pseudo-dimers.
منابع مشابه
High functionalization of 5-nitro-1H-imidazole derivatives: the TDAE approach.
We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl ...
متن کاملDIELS-ALDER REACTION OF PYRANO[3,4-b]INDOLONES WITH AN ELECTRON-DEFICIENT PYRIDAZINONE: A NEW PATHWAY TO CARBAZOLE-FUSED PYRIDAZINES
Thermally induced [4+2] cycloaddition reactions of 5-ethanesulfonyl2-methylpyridazin-3(2H)-one (2) with pyrano[3,4-b]indol-3(9H)-ones (1, 4) affords isomeric pyridazino[4,5-b]carbazolones (3a,b, 5a,b), the product ratio depending on the substitution pattern of the diene. Two carbazolocarbazoles (6, 7) were obtained as side products. The antineoplastic activity of ellipticine (5,11-dimethyl-6H-p...
متن کاملChem. Pharm. Bull. 54(2) 209—212 (2006)
heterocycles. Substitution reactions of 1(2H)-isoquinolone derivatives have been reported, however, little attention has been focused on addition reactions. Dyke et al. reported a Diels–Alder (DA) reaction of 2-methyl-1(2H)-isoquinolone derivatives as the diene. To the best of our knowledge, however, there have been no reports of a DA reaction of 1(2H)isoquinolones acting as dienophiles. DA rea...
متن کاملStructure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.
We have discovered that 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule HIF-1 pathway inhibitor, can antagonize tumor growth in animal models of cancer, but the treatment necessitates its delivery in a formulation, due to poor water solubility (<15 μg/mL; pH 7.4), evidencing that the chemotype needs further exploration of its amenability...
متن کاملSome Ternary Phenylmethoxybis(tetrazolium) Complexes of Vanadium(IV,V) and Their Constants of Association
Several liquid-liquid extraction systems containing vanadium {vanadium(IV) or vanadium(V)}, azoderivative of resorcinol {ADR: 4-(2-pyridylazo)-resorcinol (PAR) or 4-(2-thiazolylazo)-resorcinol (TAR)} and (phenylmethoxibis)tetrazolium salts {MBT: 3,3'-(3,3'-dimetoxy-4,4'-biphenylene)-bis(2,5diphenyl-2H-tetrazolium) chloride (Blue Tetrazolium, BT) or 3,3'-(3,3'-dimetoxy-4,4'-biphenylene)bis[2,5-d...
متن کامل